Why Weight Loss Programs Fail

Source: Microbiome Labs Blog September 17, 2018 The common belief in the health industry is that obesity is the result of overfeeding due to lack of self-control. The idea is that weight fluctuations can be controlled by simply balancing and manipulating caloric intake against energy expenditure. And while the increased consumption of processed sugary and fatty foods lends validity to … Read More

The microbiome and the hallmarks of cancer

Introduction The “Hallmarks of Cancer, ”proposed by Hanahan and Weinburg in 2001 and updated in 2011, logically define how a normal cell progresses to a tumorigenic state within a complex neoplastic environment.

The Human Microbiome and Cancer

Abstract Recent scientific advances have significantly contributed to our understanding of the complex connection between the microbiome and cancer. Our bodies are continuously exposed to microbial cells, both resident and transient, as well as their byproducts, including toxic metabolites. Circulation of toxic metabolites may contribute to cancer onset or progression at locations distant from where a particular microbe resides. Moreover, … Read More

A bidirectional association between the gut microbiota and CNS disease in a biphasic murine model of multiple sclerosis

Abstract The gut microbiome plays an important role in the development of inflammatory disease as shown using experimental models of central nervous system (CNS) demyelination. Gut microbes influence the response of regulatory immune cell populations in the gut-associated lymphoid tissue (GALT), which drive protection in acute and chronic experimental autoimmune encephalomyelitis (EAE). Recent observations suggest that communication between the host … Read More

Influence of diet on the gut microbiome and implications for human health

Abstract Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascular disease, and cancer. At the same time, it is now understood that diet plays a significant role in shaping the microbiome, with experiments showing that dietary alterations can induce large, temporary … Read More

My Microbiome and Me

Zhao Liping combines traditional Chinese medicine and studies of gut microbes to understand and fight obesity

Inflammatory Disease and the Human Microbiome

Abstract: The human body is a superorganism in which thousands of microbial genomes continually interact with the human genome. A range of physicaland neurological inflammatory diseases are now associated with shifts in microbiome composition. Seemingly disparate inflammatory conditions may arise from similar disruption of microbiome homeostasis.  Intracellular pathogens long associated with inflammatory disease are able to slow the innate immune … Read More

The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders

Abstract Gastrointestinal problems have been documented in Autism Spectrum Disorder (ASD). Studies have found that these disturbances may be associated with an altered gut microbiome in ASD. Furthermore, in ASD, these alterations are implicated in increased gut permeability, or “leaky gut”, which allows bacterial metabolites to cross the gut barrier, impacting neuro development during early childhood in susceptible subjects by … Read More

Identification of gut microbiome signatures associated with longevity provides a promising modulation target for healthy aging

ABSTRACT The world population is aging, which poses a significant burden to the economy and health care system. As people age, so do their gut microbiomes. Age-related changes in gut microbiome have been reported, including decreased microbial diversity and increased Proteobacteria. Recently, we characterized the gut microbiome of a group of long-living (≥90 years old) Chinese people.Interestingly, the diversity of … Read More